Reaktion #1853514

Reaktionsgleichung

2,4-dichlorophenylacetic acid

4-chloro-2-methyl-benzothiazol-5-ylamine

triethylamine

→

N-(4-chloro-2-methyl-benzothiazol-5-yl)-2-(2,4-dichloro-phenyl)-acetamide

Ausbeute 35.0%

Lösungsmittel

thionyl chloride

THF

Reaktionsbedingungen

Vorschrift

Reaction of 2,4-dichlorophenylacetic acid (163 mg, 0.79 mmol) in thionyl chloride (2 mL) then with 4-chloro-2-methyl-benzothiazol-5-ylamine (52 mg, 0.26 mmol) in presence of triethylamine (0.5 mL) in THF (3 mL) according to method B gave N-(4-chloro-2-methyl-benzothiazol-5-yl)-2-(2,4-dichloro-phenyl)-acetamide (33 mg, 0.09 mmol, 35% yield) as a white powder after crystallisation in hexane/DCM.

Quelle