Reaktion #1853508

Reaktionsgleichung

2,5-dichlorobenzoic acid

4-chloro-2-methyl-benzothiazol-5-ylamine

triethylamine

→

2,5-dichloro-N-(4-chloro-2-methyl-benzothiazol-5-yl)-benzamide

Ausbeute 52.0%

Lösungsmittel

thionyl chloride

THF

Reaktionsbedingungen

Vorschrift

Reaction of 2,5-dichlorobenzoic acid (145 mg, 0.76 mmol) in thionyl chloride (5 mL) then with 4-chloro-2-methyl-benzothiazol-5-ylamine (50 mg, 0.25 mmol) in presence of triethylamine (0.5 mL) in THF (2 mL) according to method B gave 2,5-dichloro-N-(4-chloro-2-methyl-benzothiazol-5-yl)-benzamide (50 mg, 0.13 mmol, 52% yield) as a white powder after purification by chromatography on silica gel(eluent: DCM).

Quelle