Reaktion #1852

Reaktionsgleichung

3-benzyloxy-6-hydroxymethyl-2-iodopyridine

potassium acetate

ethyl acrylate

→

solution

Ausbeute 62.0%

Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

Ausbeute 62.0%

Lösungsmittel

DMF

water

Reaktionsbedingungen

Vorschrift

To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1 ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.

Quelle