Reaktion #1850122

Reaktionsgleichung

7-benzyloxyindole-2-carboxylic acid ethyl ester

→

7-hydroxyindole-2-carboxylic acid ethyl ester

Ausbeute 86.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction solution is then filtered
2. 2
   Sonstigethe filtrate evaporated to dryness under vacuum
3. 3
   SonstigeThe residue is recrystallized from ethanol

Vorschrift

One gram of 10% palladium catalyst on active carbon is added to a solution of 22.2 g of 7-benzyloxyindole-2-carboxylic acid ethyl ester in 500 ml of ethanol and the mixture is hydrogenated for 1 hour with shaking under normal pressure. The reaction solution is then filtered and the filtrate evaporated to dryness under vacuum. The residue is recrystallized from ethanol, yielding 13.3 g of 7-hydroxyindole-2-carboxylic acid ethyl ester, mp 197°-199° C.

Quelle