Reaktion #1848746

Reaktionsgleichung

alcohol

5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)pyrazole

acetone

→

12

Ausbeute 92.0%

3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid

Ausbeute 92.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas decanted from the chromium
2. 2
   Sonstigeprecipitates on the sides of the reaction vessel
3. 3
   EinengenThe reaction solution was concentrated in vacuo
4. 4
   Waschenwashed with distilled H2O until the washes
5. 5
   Trocknendried (MgSO4)
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeCrystallization from Et2O

Vorschrift

To a solution of the alcohol 2 [(0.92 g, 2.68 millimoles (mM)] in acetone (25 ml) was added a 2N H2Cr2O7 (Jones Reagent) solution (3.02 ml, 6.04 mM) dropwise over a 10 minute time period. After stirring for 1 hour the reaction solution was decanted from the chromium precipitates on the sides of the reaction vessel. The reaction solution was concentrated in vacuo and taken up into ethyl acetate (EtOAc) (100 ml), washed with distilled H2O until the washes were clear, dried (MgSO4), filtered, and concentrated in vacuo. Crystallization from Et2O: hexane afforded 12 (0.88 g, 92%) as an off-white crystalline solid, mp=126°-128° C.

Quelle