Reaktion #1847361

Reaktionsgleichung

potassium permanganate

5-phenyl-3-methyl-1H-pyrazolo[4,3-c]isoquinoline

water

→

5-Phenyl-1H-pyrazolo[4,3-c]isoquinoline-3-carboxylic acid

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting suspension was filtered with suction through silica gel
2. 2
   Einengenafter which the filtrate was concentrated under reduced pressure
3. 3
   Sonstigethe residue was purified by means of HPLC (Merk-Hibar-Lichrospher 100-RP-18, water (0.1% trifluoroacetic acid)/acetonitrile (0.1% trifluoroacetic acid)=80/20→10/90)
4. 4
   SonstigeThe following was obtained

Vorschrift

2.1 g of potassium permanganate in 36 ml of water were added to a solution of 600 mg of 5-phenyl-3-methyl-1H-pyrazolo[4,3-c]isoquinoline in 36 ml of pyridine. The mixture was stirred at 40° C. for 12 h. The resulting suspension was filtered with suction through silica gel, after which the filtrate was concentrated under reduced pressure and the residue was purified by means of HPLC (Merk-Hibar-Lichrospher 100-RP-18, water (0.1% trifluoroacetic acid)/acetonitrile (0.1% trifluoroacetic acid)=80/20→10/90). The following was obtained: 60. C17H11N3O2 (289.30) MS (ESI) 290 (M+H)

Quelle