Reaktion #1846554

Reaktionsgleichung

3-diphenylmethyl-2,3,5,-6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

sodium hydroxide

→

desired product

3-Diphenylmethyl-2,3,5,6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid is collected by filtration
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried in vacuo at 40° C.

Vorschrift

A solution of 4.2 g. of 3-diphenylmethyl-2,3,5,-6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide in 50 ml. of 65% aqueous methanol is treated with 12 ml. of 1 N sodium hydroxide. The resulting solid is collected by filtration, washed with water and dried in vacuo at 40° C., giving the desired product, m.p. 123°-125° C.

Quelle