Reaktion #1844333

Reaktionsgleichung

triphenylphosphine

CCl4

methylamine

product

2,6-difluoro-N-[1,2,3,4-tetrahydro-1-(hydroxymethyl)-6-methoxy-1-naphthalenyl]benzamide

→

2'-(2,6-difluorophenyl)-3,4-dihydro-6-methoxy spiro [naphthalene-1(2H),4'(5'H)-oxazole]

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Vorschrift

To a suspension of 600 mg (0.0017 mol) of the product of Step D in 9 mL of acetonitrile was added 1.8 mL CCl4 and 264 mg (0.0026 mol) of methylamine. Then, 678 mg (0.0026 mol) of triphenylphosphine was added. The mixture was stirred at ambient temperature for 15 minutes.

Quelle