Reaktion #1844231

Reaktionsgleichung

methanesulphonyl chloride

6-t-butyldimethylsilyloxymethyl-4-hydroxytetrahydropyran-2-one

triethylamine

→

6-t-butyldimethylsilyloxymethyl-5,6-dihydropyran-2-one

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturbefore warming to ambient temperature
2. 2
   WaschenAfter a further 3 hours the solution was washed with water
3. 3
   Trocknendried over magnesium sulphate
4. 4
   Sonstigeevaporated

Vorschrift

To 6-t-butyldimethylsilyloxymethyl-4-hydroxytetrahydropyran-2-one (0.52 parts) in dichloromethane (40 parts) was added triethylamine (0.8 parts) and the solution was cooled to -50° C. To this solution was then added a solution of methanesulphonyl chloride (0.48 parts) in dichloromethane (8 parts) during a period of one minute. The reaction mixture was then stirred for 30 minutes at -50° C. before warming to ambient temperature. After a further 3 hours the solution was washed with water, dried over magnesium sulphate and evaporated to obtain 6-t-butyldimethylsilyloxymethyl-5,6-dihydropyran-2-one (0.4 parts).

Quelle