Reaktion #1844072

Reaktionsgleichung

sulfuric acid

water

ethyl 2-(2,4-di-t-amylphenoxy)butyrate

sodium hydroxide

→

carboxylic acid

Ausbeute 122.3%

2-(2,4-di-t-amylphenoxy)butyric acid

Ausbeute 122.3%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe hydrolysis reaction
2. 2
   SonstigeAfter completion of the reaction
3. 3
   workup.ADDITIONwas added
4. 4
   Extraktionfollowed by extraction
5. 5
   SonstigeThe water layer was separated with a separatory funnel
6. 6
   Waschenthe toluene layer was washed with water (317.9 g)
7. 7
   EinengenThen, the toluene layer was concentrated by distillation under ordinary pressure for the removal of toluene, which

Vorschrift

The above ethyl 2-(2,4-di-t-amylphenoxy)butyrate (317.9 g) and 27% aqueous sodium hydroxide (401.4 g) were placed in a 3-liter flask. The mixture was kept at 98° C. for 6 hours, and the hydrolysis reaction was completed. After completion of the reaction, the mixture was adjusted to pH 2 or lower by the addition of 40% aqueous sulfuric acid (349.9 g) and water (250 g), and toluene (317.9 g) was added thereto, followed by extraction. The water layer was separated with a separatory funnel, and the toluene layer was washed with water (317.9 g). Then, the toluene layer was concentrated by distillation under ordinary pressure for the removal of toluene, which afforded a concentrated solution (357.6 g) of the carboxylic acid compound in toluene. The analysis revealed that the concentrated solution contained the desired carboxylic acid compound in a yield of 99% on the basis of the raw material ester compound.

Quelle