Reaktion #1844002

Reaktionsgleichung

4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5yl)ethyl]-5-chloro-2-methyl-2,3-dihydrobenzo[b]furan-7-carboxamide

→

titled compound

4-Amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-2-methyl -2,3-dihydrobenzo[b]furan-7-carboxamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen, the catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe solvent was distilled out in vacuo

Vorschrift

A mixture of 4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5yl)ethyl]-5-chloro-2-methyl-2,3-dihydrobenzo[b]furan-7-carboxamide (100 mg) obtained by Example 2, 20% Pd-C (catalystic amount) and ethanol was stirred under hydrogen gas atmosphere for 20 hours. Then, the catalyst was removed by filtration and the solvent was distilled out in vacuo to afford the titled compound in quantitative amount.

Quelle