Reaktion #1838237

Reaktionsgleichung

tert-butyl 3-(3-(benzyloxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

→

title compound

Ausbeute 99.6%

benzyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Ausbeute 99.6%

Lösungsmittel

hydrogen chloride

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated in vacuo

Vorschrift

A solution of tert-butyl 3-(3-(benzyloxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (913 mg, 1.646 mmol, 1 equiv) in 4M hydrogen chloride solution in dioxane was stirred at ambient temperature for 4-5 h. The mixture was concentrated in vacuo and the residue was lyophilized to afford the hydrogen chloride salt of the title compound as a cream solid (747 mg, quant); MS for C28H29N3O3 m/z 456.04 (M+H)+.

Quelle