Reaktion #1838

Reaktionsgleichung

nitric acid

sulfuric acid

3-trifluoromethoxybenzoic acid

→

2-Nitro-5-trifluoromethoxybenzoic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling
2. 2
   TemperaturThe reaction mixture was heated at 50°-55° C. for 1 hour
3. 3
   Temperaturafter cooling
4. 4
   workup.ADDITIONwas poured onto ice
5. 5
   Filtrationthe residue was filtered off with suction
6. 6
   Sonstigeto give
7. 7
   Sonstigeafter drying
8. 8
   Sonstige8.8 g of product, melting point 90°-93° C. (sintering at 85° C.)

Vorschrift

29.7 ml of nitric acid were added dropwise to 76.5 ml of concentrated sulfuric acid, while cooling and stirring, and 9.0 g (43.7 mmol) of 3-trifluoromethoxybenzoic acid were then added. The reaction mixture was heated at 50°-55° C. for 1 hour and, after cooling, was poured onto ice, and the residue was filtered off with suction to give, after drying, 8.8 g of product, melting point 90°-93° C. (sintering at 85° C.).

Quelle