Reaktion #1836989

Reaktionsgleichung

6-Bromo-1H-pyrrolo[2,3-b]pyridine

acetic acid

hexamethylenetetramine

→

6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde

Ausbeute 25.0%

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitated solid was collected by filtration

Vorschrift

6-Bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 0.14 mmol) was successively added with acetic acid (0.1 mL), water (0.2 mL), and hexamethylenetetramine (0.028 g, 0.20 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration to obtain 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.008 g, 25%).

Quelle