Reaktion #1836686

Reaktionsgleichung

tert-butyl (3-hydroxycyclohexyl)carbamate

TFA

→

crude product

3-Amino-1-methylcyclohexanol

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling in an ice bath
2. 2
   SonstigeThe resulting reaction mixture
3. 3
   EinengenThe mixture was concentrated

Vorschrift

To a solution of crude tert-butyl (3-hydroxycyclohexyl)carbamate (4.0 g, crude) in DCM (40 mL) was added TFA (20 mL) under cooling in an ice bath. The resulting reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated to give a crude product (3.0 g, crude), which was used in the next step without further purification. MS (ESI) m/z 130.1 [M+H]+.

Quelle