Reaktion #1836142

Reaktionsgleichung

N-[1-(ethylsulfanyl)isobutylidene]-4-bromoaniline

benzoylhydrazine

1-butanol

→

4-(4-bromophenyl)-5-isopropyl-3-phenyl-4H-1,2,4-triazole

Ausbeute 28.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 300 mL recovery flask were put
2. 2
   workup.DISTILLATIONAfter that, 1-butanol was distilled off
3. 3
   Sonstigeto give a solid
4. 4
   Sonstigewas irradiated with ultrasonic waves
5. 5
   Filtrationa white solid was collected by gravity filtration, so that 2.8 g of white powder of 4-(4-bromophenyl)-5-isopropyl-3-phenyl-4H-1,2,4-triazole
6. 6
   Sonstigewas obtained in a yield of 28%
7. 7
   SonstigeThe reaction scheme of Step 4

Vorschrift

In a 300 mL recovery flask were put 13 g (44 mmol) of N-[1-(ethylsulfanyl)isobutylidene]-4-bromoaniline, 3.9 g (29 mmol) of benzoylhydrazine, and 40 mL of 1-butanol, and the mixture was heated and refluxed at 130° C. for 10 hours. After that, 1-butanol was distilled off to give a solid. A methanol suspension of this solid was irradiated with ultrasonic waves, and a white solid was collected by gravity filtration, so that 2.8 g of white powder of 4-(4-bromophenyl)-5-isopropyl-3-phenyl-4H-1,2,4-triazole was obtained in a yield of 28%. The reaction scheme of Step 4 is shown in (b-4) below.

Quelle