Reaktion #1835764

Reaktionsgleichung

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

trifluoroacetic acid

→

1-(5-bromopyridin-2-yl)-4-oxocyclohexanecarbonitrile

Ausbeute 94.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Sonstigethe solvent and trifluoroacetic acid were evaporated
3. 3
   SonstigeThe obtained residue was purified with silica gel column chromatography (n-hexane:ethyl acetate)

Vorschrift

To 8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile (3.4 g) described in Reference Example 82 was added trifluoroacetic acid (4.1 ml) at room temperature, and stirred at the same temperature for 22 hours. After completion of the reaction, the solvent and trifluoroacetic acid were evaporated. The obtained residue was purified with silica gel column chromatography (n-hexane:ethyl acetate) to give 1-(5-bromopyridin-2-yl)-4-oxocyclohexanecarbonitrile (2.78 g) as a white solid.

Quelle