Reaktion #1835100

Reaktionsgleichung

sodium carbonate

4-(cyclohexyloxy)phenylboronic acid

3-bromo-5-chloropyridin-2-amine

→

title compound

Ausbeute 48.4%

5-chloro-3-[4-(cyclohexyloxy)phenyl]pyridin-2-amine

Ausbeute 48.4%

Lösungsmittel

DME

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   Einengenthe mixture was concentrated in vacuo
3. 3
   SonstigeThe residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane)

Vorschrift

A mixture of sodium carbonate (307 mg), tetrakis(triphenylphosphine)palladium(0) (50.1 mg), 4-(cyclohexyloxy)phenylboronic acid (414 mg) and 3-bromo-5-chloropyridin-2-amine (300 mg) in DME (15 mL) and water (3 mL) was stirred at 80° C. for 5 hr. Silica gel was added and the mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (212 mg) as a yellow gum.

Quelle