Reaktion #1831470

ord-36ecfcbaccb6480a9af566e790c395e6

Reaktionsgleichung

CCOC(=O)c1cc2c(Br)c(Oc3ccc(OC)c(C(=O)c4ccc(F)cc4)c3)c(Br)cc2o1
ethyl 4,6-dibromo-5-[3-(4-fluorobenzoyl)-4-methoxyphenoxy]-1-benzofuran-2-carboxylate
CCS.[Al+3].[Cl-].[Cl-].[Cl-]
AlCl3 ethanethiol
→
CCOC(=O)c1cc2c(Br)c(Oc3ccc(O)c(C(=O)c4ccc(F)cc4)c3)c(Br)cc2o1
ethyl 4,6-dibromo-5-[3-(4-fluorobenzoyl)-4-hydroxyphenoxy]-1-benzofuran-2-carboxylate
Ausbeute 47.0%

Edukte

CCOC(=O)c1cc2c(Br)c(Oc3ccc(OC)c(C(=O)c4ccc(F)cc4)c3)c(Br)cc2o1
ethyl 4,6-dibromo-5-[3-(4-fluorobenzoyl)-4-methoxyphenoxy]-1-benzofuran-2-carboxylate
CCS.[Al+3].[Cl-].[Cl-].[Cl-]
AlCl3 ethanethiol

Reagenzien

Keine

Lösungsmittel

CCOCC
Ether

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Ether cleavage of 108 mg of ethyl 4,6-dibromo-5-[3-(4-fluorobenzoyl)-4-methoxyphenoxy]-1-benzofuran-2-carboxylate with AlCl3/ethanethiol, in analogy with example . . . , yields 49 mg (47%) of ethyl 4,6-dibromo-5-[3-(4-fluorobenzoyl)-4-hydroxyphenoxy]-1-benzofuran-2-carboxylate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07015246B2uspto-grants-2006_03