Reaktion #1827481

Reaktionsgleichung

4-bromo-2-ethoxycarbonylbenzo[b]furan

sodium borohydride

ethyl acetate

methanol

→

4-bromo-2-hydroxymethylbenzofuran

Ausbeute 85.3%

Lösungsmittel

water

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   Sonstigethe layers were separated
3. 3
   WaschenThe organic layer was washed with water and brine
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated

Vorschrift

To a solution of 4-bromo-2-ethoxycarbonylbenzo[b]furan (0.5 g) in tetrahydrofuran (5 ml) was slowly added sodium borohydride (0.21 g) at room temperature. After 5 minutes, methanol (0.5 ml) was added thereto dropwise. The reaction mixture was stirred at room temperature for one hour and then ethyl acetate and water were added thereto. The mixture was adjusted to pH 5, and the layers were separated. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated to afford 4-bromo-2-hydroxymethylbenzofuran (0.36 g).

Quelle