Reaktion #1826061

Reaktionsgleichung

Triethylamine

6-chloronaphth-2-ylsulphonyl chloride

glycine methyl ester hydrochloride

→

methyl N-(6-chloronaphth-2-ylsulphonyl)glycine

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was partitioned between ethyl acetate and water
2. 2
   WaschenThe organic phase was washed with brine
3. 3
   Trocknendried (MgSO4)
4. 4
   Sonstigeevaporated
5. 5
   SonstigeThe residue was recrystallised from methanol

Vorschrift

Triethylamine (0.278 ml) was added to a stirred mixture of 6-chloronaphth-2-ylsulphonyl chloride (0.522 g), glycine methyl ester hydrochloride (0.251 g) and methylene chloride (10 ml) and the mixture was stirred at ambient temperature for 1 hour. The mixture was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried (MgSO4) and evaporated. The residue was recrystallised from methanol to give methyl N-(6-chloronaphth-2-ylsulphonyl)glycine (0.46 g).

Quelle