Reaktion #1822504

Reaktionsgleichung

sodium hydride

8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane

trimethylsilylacetylene

→

8-trimethylsilylethynyl-1,4-dioxaspiro[4.5]decane

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONUpon completion of addition
2. 2
   workup.STIRRINGthe reaction mixture is stirred at ambient temperature for about one hour
3. 3
   workup.ADDITIONUpon completion of addition
4. 4
   Temperaturto warm to ambient temperature where it
5. 5
   workup.STIRRINGis stirred during about 18 hours
6. 6
   EinengenAfter this time the reaction mixture is concentrated under reduced pressure to a residue
7. 7
   workup.STIRRINGThe residue is stirred in water
8. 8
   Extraktionthe mixture is extracted with three 50 mL portions of diethyl ether
9. 9
   WaschenThe combined extracts are washed with water
10. 10
    Trocknendried with magnesium sulfate
11. 11
    FiltrationThe mixture is filtered
12. 12
    Einengenthe filtrate is concentrated under reduced pressure

Vorschrift

Under a nitrogen atmosphere, a mixture of 3.2 grams (0.08 mole) of sodium hydride (60% in mineral oil) in 25 mL of tetrahydrofuran is stirred, and a solution of 7.9 grams (0.08 mole) of trimethylsilylacetylene in 15 mL of tetrahydrofuran is added dropwise. Upon completion of addition, the reaction mixture is stirred at ambient temperature for about one hour. The reaction mixture is then cooled to 0° C., and a solution of 18.9 grams (0.08 mole) of 8-methylsulfonyloxy-1,4-dioxaspiro[4.5]decane in 25 mL of tetrahydrofuran is added dropwise. Upon completion of addition, the reaction mixture is allowed to warm to ambient temperature where it is stirred during about 18 hours. After this time the reaction mixture is concentrated under reduced pressure to a residue. The residue is stirred in water, and the mixture is extracted with three 50 mL portions of diethyl ether. The combined extracts are washed with water and dried with magnesium sulfate. The mixture is filtered, and the filtrate is concentrated under reduced pressure, yielding 8-trimethylsilylethynyl-1,4-dioxaspiro[4.5]decane.

Quelle