Reaktion #1822321

Reaktionsgleichung

sodium hydride

4-amino-3-methyl -5,6,7,8-tetrahydrothieno[2,3-b]quinoline

ammonium chloride

methyl 2-oxo-1-pyrrolidine acetate

→

2-(2-oxopyrrolidin-1-yl)-N-(3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-yl)acetamide

Lösungsmittel

N-methylpyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter the stirring at 50° C. for 20 minutes
2. 2
   Temperaturthe mixture was cooled to 15° C.

Vorschrift

Into a suspension of 1.26 g of sodium hydride (60% content) in 15 ml of N-methylpyrrolidone, was added 3.28 g of 4-amino-3-methyl -5,6,7,8-tetrahydrothieno[2,3-b]quinoline at room temperature. The mixture was heated to 50° C. and stirred for 40 minutes. Thereafter, 4.72 g of methyl 2-oxo-1-pyrrolidine acetate was added dropwise to the mixture at 50° C. over a period of 30 minutes. After the stirring at 50° C. for 20 minutes, the mixture was cooled to 15° C. and poured into 130 ml aqueous solution containing 13.5 g of ammonium chloride.

Quelle