Reaktion #1821771

Reaktionsgleichung

2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile

chloroformamidine hydrochloride

→

2,4-diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline

Ausbeute 29.4%

Lösungsmittel

2-methoxyethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared in a manner analogous to that of Step E of Example 1
2. 2
   SonstigeThe solid was recrystallized from methanol

Vorschrift

This compound was prepared in a manner analogous to that of Step E of Example 1, using 1.5 grams (0.005 mole) of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile and 0.7 gram (0.006 mole) of chloroformamidine hydrochloride in 10 mL of 2-methoxyethyl ether. The solid was recrystallized from methanol, yielding 0.5 gram of 2,4-diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline. The NMR spectrum was consistent with the proposed structure; however, methanol was present in the sample.

Quelle