Reaktion #1816461

Reaktionsgleichung

compound h

1,3-dimethyl-6-[4-(3-aminopropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

4-nitrofluorobenzene

→

1,3-dimethyl-6-[4-(3-[4-nitroanilino]-propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturfor cooling
2. 2
   Filtrationthe precipitated crystals were collected by filtration
3. 3
   Waschenwashed
4. 4
   Sonstigedried

Vorschrift

2.50 g of the previously obtained compound h and 1.90 g of 4-nitrofluorobenzene were added to 20 ml of dimethyl sulfoxide, and the resultant mixture was then heated at 80° C. for 3 hours. After the mixture was allowed to stand for cooling, the precipitated crystals were collected by filtration, washed, and then dried to obtain 2.75 g of 1,3-dimethyl-6-[4-(3-[4-nitroanilino]-propyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione (Compound g).

Quelle