Reaktion #1816157

Reaktionsgleichung

AlCl3

acid chloride

(±)-2-Methyl-3-(2-tolyl)-propionyl chloride

→

(±)-2,4-Dimethylindanone

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONIt was poured onto ice/HCl
2. 2
   Extraktionextracted with toluene
3. 3
   Waschenwashed with H2O, NaHCO3 solution and NaCl solution
4. 4
   Sonstigedried
5. 5
   workup.DISTILLATIONdistilled (109° C./1 mmHg)
6. 6
   Sonstigechromatographed (n-hexane/ethyl acetate 6:1, rF =0.44)

Vorschrift

36 g (270 mmol) of AlCl3 were added to 17.7 g (90 mmol) of acid chloride f4 in 50 ml of toluene in the course of 20 minutes, and the mixture was stirred at 80° C. for 4 hours. It was poured onto ice/HCl, extracted with toluene, washed with H2O, NaHCO3 solution and NaCl solution, dried and distilled (109° C./1 mmHg) or chromatographed (n-hexane/ethyl acetate 6:1, rF =0.44).

Quelle