Reaktion #1810805

ord-941be3564bea4ff8bf63eedef6b4b1ab

Reaktionsgleichung

CC(C)(C)OC(=O)N[C@H]1CC[C@H](NC(N)=S)CC1
(trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester
CI
methyliodide
→
CSC(=N)N[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(2-methyl-isothioureido)-cyclohexyl]-carbamic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)N[C@H]1CC[C@H](NC(N)=S)CC1
(trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester
CI
methyliodide

Reagenzien

Keine

Lösungsmittel

CO
MeOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeFrom the mixture obtained solvent
  2. 2
    Sonstigeis evaporated

Vorschrift

A mixture of 1.19 g of (trans-4-thioureido-cyclohexyl)-carbamic acid tert-butyl ester and 0.41 ml of methyliodide in 50 ml of MeOH is stirred at RT. From the mixture obtained solvent is evaporated and [trans-4-(2-methyl-isothioureido)-cyclohexyl]-carbamic acid tert-butyl ester in the form of a hydrolodide is obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07485632B2uspto-grants-2009_02