Reaktion #1807982

Reaktionsgleichung

(2R,6R) 4-[2-(9-fluorenylmethyloxycarbonylamino)-6,7-bis(palmitoyloxy)-4-thiaheptanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

piperidine

→

title compound

Ausbeute 97.0%

(2R,6R) 4 -[2-amino-6,7-bis(palmitoyloxy)-4-thiaheptanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester

Ausbeute 97.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter solvent concentration under reduced pressure
2. 2
   Sonstigethe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1 to 1:3)

Vorschrift

A solution of (2R,6R) 4-[2-(9-fluorenylmethyloxycarbonylamino)-6,7-bis(palmitoyloxy)-4-thiaheptanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester as obtained in Reference Example 38 (243 mg) in dichloromethane (0.5 ml)-piperidine (2 ml) was stirred at room temperature for 30 minutes. After solvent concentration under reduced pressure, the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1 to 1:3) to yield the title compound (195 mg, yield 97%) as a colorless wax-like substance.

Quelle