Reaktion #1807702

ord-dba6e328d4794d15a231434a31e2b557

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine
CCCCCCCC(=O)N1CCC[C@H]1C(=O)O
N-octanoyl-L-proline
→
CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1
title compound
Ausbeute 55.2%
CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-2-(1-Hydroxy-2-phenoxyethyl)-1-(N-octanoyl-L-prolyl)pyrrolidine
Ausbeute 55.2%

Edukte

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine
CCCCCCCC(=O)N1CCC[C@H]1C(=O)O
N-octanoyl-L-proline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By the same procedure as in Example 1-D), while using (2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine (1.50 g) and N-octanoyl-L-proline (1.18 g), there was obtained 1.16 g of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05506256uspto-grants-1996_04