Reaktion #1807699

ord-d08ea03474d84d73bf64a05e119a4518

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine
CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
N-(tert-butoxycarbonyl)-L-proline
→
CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1
title compound
CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-1-[N-(tert-Butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine

Edukte

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccccc1
(2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine
CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
N-(tert-butoxycarbonyl)-L-proline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethere was obtained 2

Vorschrift

By the same procedure as in Example 26-D), while using (2S)-1-(tert-butoxycarbonyl)-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine (1.93 g) and N-(tert-butoxycarbonyl)-L-proline (1.36 g), there was obtained 2. i0 g of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05506256uspto-grants-1996_04