Reaktion #1807368

Reaktionsgleichung

Triethylphosphite

L-valine

hydrocinnamaldehyde

→

title compound

N-(1-Diethoxyphosphinyl-3-phenylpropyl)-L-valine

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter evaporating the solvent
2. 2
   workup.DISSOLUTIONthe solid is dissolved in 5% sodium bicarbonate solution
3. 3
   Waschenwashed with ether
4. 4
   ExtraktionThe aqueous mixture is extracted with ethyl acetate
5. 5
   Sonstigedried
6. 6
   Sonstigeevaporated

Vorschrift

Triethylphosphite (7.09 g, 42.7 mmol), L-valine (5 g, 42.7 mmol) and hydrocinnamaldehyde (5.73 g, 42.7 mmol) are heated in acetic acid (15 mL) at 80° C. for 4 h. After evaporating the solvent, the solid is dissolved in 5% sodium bicarbonate solution, washed with ether and acidified to pH =4. The aqueous mixture is extracted with ethyl acetate, dried and evaporated to afford the title compound.

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