Reaktion #1802875

Reaktionsgleichung

1-(4-bromo-phenyl)-3-dimethylamino-propenone

4-guanidino-benzenesulfonamide

NMP

→

white solid

Ausbeute 99.9%

4-{[4-(4-bromophenyl)pyrimidin-2-yl]amino}benzenesulfonamide

Ausbeute 99.9%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled to room temperature
2. 2
   Filtrationfiltered
3. 3
   WaschenThe solid residue is washed with water
4. 4
   Sonstigedried

Vorschrift

A flask is charged with the 1-(4-bromo-phenyl)-3-dimethylamino-propenone (1.05 g, 4.10 mmol), 4-guanidino-benzenesulfonamide (1.33 g, 6.20 mmol), and NMP (30 ml). The reaction mixture is stirred at 120° C. for 20 h. The reaction mixture is cooled to room temperature, diluted with water, and filtered. The solid residue is washed with water and dried to yield 1.66 g of a white solid. MS (ESI) m/z 405.1; HRMS: calcd for C16H13BrN4O2S+H+, 405.00153; found (ESI-FTMS, [M+H]1+), 405.00158.

Quelle