Reaktion #1798212

Reaktionsgleichung

257

4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

2-phenylacetyl isothiocyanate

→

title compound 258a

Ausbeute 15.0%

N-(4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Ausbeute 15.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Wascheneluted with a gradient of gradient EtOAc/hexane, 1:1 to 2:1
2. 2
   Sonstigeto provide a beige solid which
3. 3
   Sonstigewas triturated with diethyl ether

Vorschrift

To a suspension of the 257 (134.6 mg, 0.418 mmol) in THF (4.2 mL) was added 2-phenylacetyl isothiocyanate (111 mg, 0.627 mmol). The reaction mixture was stirred for 1 hr at room temperature, transferred onto a chromatography column and eluted with a gradient of gradient EtOAc/hexane, 1:1 to 2:1, to provide a beige solid which was triturated with diethyl ether to afford title compound 258a (31 mg, 15% yield) as a white solid. Characterization of 258a is provided in the table 23.

Quelle