Reaktion #1797956

Reaktionsgleichung

4-(3-chloropropoxy)-2-fluorobenzoic acid

thionyl chloride

→

4-(3-chloropropoxy)-2-fluorobenzoyl chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture is then concentrated under reduced pressure

Vorschrift

4-(3-chloropropoxy)-2-fluorobenzoic acid i78 (0.68 g, 2.92 mmol, 1 eq) is refluxed in thionyl chloride (4.27 ml, 57.46 mmol, 20 eq) for 3 hours. The mixture is then concentrated under reduced pressure to give 0.73 g of crude 4-(3-chloropropoxy)-2-fluorobenzoyl chloride i80, which is used in the next step without purification.

Quelle