Reaktion #1797954

Reaktionsgleichung

2-fluoro-4-hydroxybenzoic acid

bromochloropropane

potassium carbonate

→

3-chloropropyl 4-(3-chloropropoxy)-2-fluorobenzoate

Ausbeute 155.3%

Lösungsmittel

methyl ethyl ketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Waschenwashed with acetone
3. 3
   Einengenconcentrated under vacuum

Vorschrift

2-fluoro-4-hydroxybenzoic acid (1 g, 6.41 mmol, 1 eq) is reacted with bromochloropropane (0.82 ml, 8.33 mmol, 1.3 eq) in the presence of potassium carbonate (1.77 g, 12.81 mmol, 2 eq) in methyl ethyl ketone (18 ml) at 80° C. overnight, filtered, washed with acetone and concentrated under vacuum to afford 2 g of 3-chloropropyl 4-(3-chloropropoxy)-2-fluorobenzoate i76.

Quelle