Reaktion #1797493

Reaktionsgleichung

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

Ausbeute 84.6%

Lösungsmittel

—

ice water

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   SonstigeAfter completion of the reaction
3. 3
   Sonstigethe reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   SonstigeCrystals precipitated
6. 6
   Filtrationwere filtered off
7. 7
   Waschenwashed with 1,000 ml of water
8. 8
   SonstigeThe crystals obtained
9. 9
   Sonstigewere dried

Vorschrift

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

Quelle