Reaktion #1797478

ord-49530173db4a46ca88018fc46e3407e0

Reaktionsgleichung

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
chlorpheniramine maleate
→
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Chlorpheniramine

Edukte

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
chlorpheniramine maleate
—
ion-exchange

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Waschenthe product washed with USP water
  2. 2
    SonstigeThe wet cake was dried
  3. 3
    Filtrationsieved through a US Std #30 mesh screen

Vorschrift

Chlorpheniramine polistirex was prepared by mixing 3.12 kg of chlorpheniramine maleate with 26.00 kg of ion-exchange resin particles (AMBERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 30° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The chlorpheniramine content of the dried product was equivalent to approximately 11% by weight.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07790201B2uspto-grants-2010_09