Reaktion #1791563

Reaktionsgleichung

acetylsalicylic acid

acetylsalicylic acid

1,2-propanediol

monoolein

glyceryl monooleate

1,2-propanediol ethanol

→

1,4-butanediol

1,3-propanediol

1,2-butanediol

1,3-butanediol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigegives an excellent blanching grade of about 3 about 2 hours post-application

Vorschrift

Anti-inflammatory compositions of the type described hereinabove containing acetylsalicylic acid, 1,2-propanediol, ethanol and monoolein are tested in the foregoing manner. In a typical test procedure, a composition comprising 3% by weight acetylsalicylic acid in a 1:1 (wt.) 1,2-propanediol/ethanol base containing 1% glyceryl monooleate gives an excellent blanching grade of about 3 about 2 hours post-application. Replacement of the 1,2-propanediol in the above composition with 1,3-propanediol, 1,2-butanediol, 1,3-butanediol and 1,4-butanediol gives blanching grades of 3.2, 2.6, 2.8 and 2.6, respectively. Similarily, replacement of the ethanol with 1-propanol and 2-propanol gives blanching grades of 3.1 and 3.0, respectively.

Quelle