Reaktion #1790163

Reaktionsgleichung

3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one

→

3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one

Ausbeute 126.7%

Lösungsmittel

4-aminobutanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONthe majority of the 4-aminobutanol was then distilled off under vacuum
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   Sonstigeto crystallize out the product
4. 4
   Filtrationthe mixture was filtered
5. 5
   WaschenThe product was washed
6. 6
   Sonstigedried

Vorschrift

20 g of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one were stirred in 100 ml of 4-aminobutanol at 175° C. for 24 hours and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water to crystallize out the product and the mixture was filtered. The product was washed and dried to obtain 16.2 g of 3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one.

Quelle