Reaktion #1789684

Reaktionsgleichung

5-fluoro-3-methyl-2-acetylbenzo [b] furan

bromine

bromine

→

5-fluoro-3-methyl-2-(α-bromoacetyl) benzo [b] furan

Ausbeute 70.2%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   FiltrationThen, the solution is filtered

Vorschrift

In this Reference Example, 38.4 g of 5-fluoro-3-methyl-2-acetylbenzo [b] furan is dissolved in 200 ml of acetic acid and 32.0 g of bromine is added dropwise thereto at room temperature. The mixture solution is then stirred for 30 minutes at room temperature, whereby the color of bromine disappears and crystals are deposited from the solution. Then, the solution is filtered to obtain 38.0 g of 5-fluoro-3-methyl-2-(α-bromoacetyl) benzo [b] furan as crystals. (Yield: 70%). Melting point of the desired compound recrystallized from ethanol is 120°-123° C.

Quelle