Reaktion #1787929

Reaktionsgleichung

hydrochloric acid

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one-2-oxide

aminoguanidine hydrochloride

→

7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnolin-2-oxide hydrochloride

Ausbeute 151.5%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction solution was cooled to room temperature
2. 2
   Filtrationthe resulting crystals were filtered
3. 3
   Sonstigedried

Vorschrift

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one-2-oxide (116 mg) and aminoguanidine hydrochloride (49 mg) were added ethanol (3 ml) and concentrated hydrochloric acid (0.05 ml), and the mixture was stirred at 100° C. (bath temperature) for 3 hours. The reaction solution was cooled to room temperature, and the resulting crystals were filtered and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnolin-2-oxide hydrochloride (Compound 160) (116 mg) as colorless crystals.

Quelle