Reaktion #1787854

Reaktionsgleichung

hydrochloric acid

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one

aminoguanidine hydrochloride

→

7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride

Ausbeute 174.7%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 1.5 hours
2. 2
   Temperaturcooled
3. 3
   SonstigePrecipitated crystals
4. 4
   Filtrationwere filtered
5. 5
   Waschenwashed with ethanol
6. 6
   Sonstigedried

Vorschrift

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.218 g) and aminoguanidine hydrochloride (94 mg) were added ethanol (5 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 129) (0.255 g) as crystals.

Quelle