Reaktion #1787

Reaktionsgleichung

2,4-dimethyl-3-carboethoxypyridine

lithium aluminum hydride

→

2,4-dimethyl-3-hydroxymethylpyridine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthen cooled to 0° C.
2. 2
   Sonstigequenched with EtOAc (2.5 mL)
3. 3
   FiltrationThe solution was filtered
4. 4
   Sonstigethe solvent removed under reduced pressure

Vorschrift

The 2,4-dimethyl-3-carboethoxypyridine (11.3 g, 63.1 mmol) in distilled THF (375 mL) under nitrogen was cooled to 0° C. and lithium aluminum hydride (1M in THF, 63.1 mL) was added dropwise. The reaction was stirred for 18 hours at room temperature then cooled to 0° C. and quenched with EtOAc (2.5 mL), then H2O (2.5 mL), then 15% NaOH (2.5 mL), followed by H2O (7.5 mL). The solution was filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-hydroxymethylpyridine.

Quelle