Reaktion #1785285

Reaktionsgleichung

[1,3]Dioxolo[4,5-f][1,3]benzothiazole

5-bromo-N-methylpyridin-2-amine

2-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole

→

title compound

Ausbeute 35.7%

5-[1,3]Dioxolo[4,5-f][1,3]benzothiazol-6-yl-N-methylpyridin-2-amine

Ausbeute 35.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude material was purified by flash chromatography (Heptane/EtOAc 1:1)

Vorschrift

To [1,3]Dioxolo[4,5-f][1,3]benzothiazole (98 mg, 0.55 mmol) and 5-bromo-N-methylpyridin-2-amine (112 mg, 0.60 mmol) were subjected to the procedure used for the preparation of 2-(2-methoxypyrimidin-5-yl)-1,3-benzothiazole, with the following exceptions: 5 mol % bis(tri-t-butylphosphine) palladium (0) was used and the reaction was heated under argon at 170° C. in a microwave oven for 30 min. The crude material was purified by flash chromatography (Heptane/EtOAc 1:1) to give the title compound (56 mg) as a yellow solid. 1H NMR δ 8.62 (d, 1H) 7.94 (dd, 1H) 7.61 (s, 1H) 7.47 (s, 1H) 7.19 (q, 1H) 6.57 (d, 1H) 6.13 (s, 2H) 2.85 (d, 3H); MS m/z (M+H) 286.

Quelle