Reaktion #1784912

Reaktionsgleichung

1-(4-chlorophenyl)cyclopropanecarboxylic acid

oxalyl chloride

citric acid

(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one methanesulfonate

→

title compound

Ausbeute 95.0%

(1S,4S)-5-(1-(4-chlorophenyl)cyclopropanecarbonyl)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one

Ausbeute 95.0%

Lösungsmittel

toluene

toluene

triethylamine

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred at 22° C. for 16 hr
2. 2
   Sonstigethe phases were separated
3. 3
   ExtraktionThe aqueous layer was extracted with ethyl acetate
4. 4
   WaschenThe combined organic layers were washed with brine (20 mL)
5. 5
   Trocknendried over sodium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeThe crude mixture was crystallized in a mixture of dichloromethane, ethyl acetate and heptane

Vorschrift

1-(4-chlorophenyl)cyclopropanecarboxylic acid (8.58 g) and dimethylformamide (136 mg) were suspended in toluene (20 mL). The mixture was cooled down to room temperature then a solution of oxalyl chloride (5.25 g) in toluene (6.7 mL) was dropped within 10 min. The reaction mixture was stirred at 0° C. for 30 min and at room temperature for 3 h. At 0-5° C., (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one methanesulfonate (CAS #: 769167-53-5; 8 g) and tetrahydrofuran (13.2 mL) were added to the reaction mixture, followed by a dropwise addition of triethylamine (14.5 g). The mixture was stirred at 22° C. for 16 hr. An aqueous solution of citric acid (10%, 30 mL) was added and the phases were separated. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, filtered and concentrated in vacuo. The crude mixture was crystallized in a mixture of dichloromethane, ethyl acetate and heptane to yield 10.6 g (95%) of the title compound as a white solid. MS (ESI): m/z=292.07 [M+H]+.

Quelle