Reaktion #1784135

Reaktionsgleichung

acetonitrile

4-aminothiophenol

triethylamine

1-iodoheptafluoro-n-propane

→

desired product

Ausbeute 63.2%

4-(heptafluoro-n-propylthio) aniline

Ausbeute 63.2%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with aqueous 1N sodium hydroxide solution
2. 2
   Sonstigepurified by silica gel column chromatography

Vorschrift

To 20 ml of an acetonitrile solution of 1.25 g of 4-aminothiophenol and 1.11 g of triethylamine was added 5.91 g of 1-iodoheptafluoro-n-propane. The resulting mixture was stirred at room temperature for 3 hours, diluted with ether, and then washed with aqueous 1N sodium hydroxide solution, purified by silica gel column chromatography using an eluent (development solvent; hexane:ethyl acetate=4:1) to obtain 1.85 g of the desired product (Yield: 63%).

Quelle