Reaktion #1782301

Reaktionsgleichung

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

TFA

→

title compound

[[3′,5-Dichloro-4′-(methylsulfonyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo, water
2. 2
   workup.ADDITIONwas added
3. 3
   Extraktionthe mixture was extracted with dichloromethane (three times)
4. 4
   TrocknenThe organic extracts were dried (MgSO4)
5. 5
   Sonstigeevaporated
6. 6
   Sonstigetriturated with ether

Vorschrift

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

Quelle