Reaktion #1781945

ord-28c6aaf17ecc4e7ead3f0558f57bb518

Reaktionsgleichung

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
Cc1cc(N(C)S(C)(=O)=O)ncc1Br
product
Cc1cc(N(C)S(C)(=O)=O)ncc1Br
N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide
→
Cc1cc(N(C)S(C)(=O)=O)ncc1-c1cc(Cl)ccc1O[C@@H](C)C(=O)O
title compound
Cc1cc(N(C)S(C)(=O)=O)ncc1-c1cc(Cl)ccc1O[C@@H](C)C(=O)O
2-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2S)-propanoic acid

Edukte

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
Cc1cc(N(C)S(C)(=O)=O)ncc1Br
product
Cc1cc(N(C)S(C)(=O)=O)ncc1Br
N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the method of example 155 using the product from step (ii) and the product from example 151 step (iv). Yield 0.125 g.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08158820B2uspto-grants-2012_04