Reaktion #1781935

ord-238b2211693e4c3ab23a7914dc2149f1

Reaktionsgleichung

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
O=S(=O)(c1ccc(Br)cc1)N1CCC1
1-[(4-bromophenyl)sulfonyl]azetidine
→
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N2CCC2)cc1)C(=O)O
title compound
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N2CCC2)cc1)C(=O)O
2-[[4′-(1-Azetidinylsulfonyl)-5-chloro[1,1′-biphenyl]-2-yl]oxy]-(2S)-propanoic acid

Edukte

C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
O=S(=O)(c1ccc(Br)cc1)N1CCC1
1-[(4-bromophenyl)sulfonyl]azetidine

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the method of example 144 step (i) using the product from example 151 step (iv), 1-[(4-bromophenyl)sulfonyl]azetidine and THF as solvent. Yield 0.028 g.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08158820B2uspto-grants-2012_04