Reaktion #1781932

ord-633fe93bad1f424bbc721c3efd4c7359

Reaktionsgleichung

CN(C)S(=O)(=O)c1ccc(Br)c(F)c1
product
CN(C)S(=O)(=O)c1ccc(Br)c(F)c1
4-Bromo-N,N-dimethyl-3-fluorobenzenesulfonamide
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid
→
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N(C)C)cc1F)C(=O)O
title compound
C[C@H](Oc1ccc(Cl)cc1-c1ccc(S(=O)(=O)N(C)C)cc1F)C(=O)O
[[5-Chloro-4′-[(dimethylamino)sulfonyl]-2′-fluoro[1,1′-biphenyl]-2-yl]oxy]-(2S)-propanoic acid

Edukte

CN(C)S(=O)(=O)c1ccc(Br)c(F)c1
product
CN(C)S(=O)(=O)c1ccc(Br)c(F)c1
4-Bromo-N,N-dimethyl-3-fluorobenzenesulfonamide
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
product
C[C@H](Oc1ccc(Cl)cc1B(O)O)C(=O)O
2-(2-Borono-4-chlorophenoxy)-(2S)-propanoic acid

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by the method of example 144 step (i) using the product from step (i), the product from example 151 step (iv) and THF as solvent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08158820B2uspto-grants-2012_04